What does it mean if 3 drinks makes me really nauseated, and pain killers is the same?

I get easily sick to my stomach and vomit if i take alcohol, and vicodin or other pain killers only makes me sick. My marijuana tolerance is extremely low, one hit makes me really high.... IN SPITE of the fact i have smoked it daily for 6 years. I am a full grown 24 year old man and I weigh 150lbs 6ft tall. am I an unusual genotype?